Name | Amodiaquine HCL |
Synonyms | AMODIAQUINE HCL Amodiaquine HCL AMODIAQUIN HYDROCHLORIDE AmodiaquineHydrochloride AMODIAQUINE 2HCL DIHYDRATE AMODIAQUIN DIHYDROCHLORIDE AMODIAQUINE DIHYDROCHLORIDE Amodiaquine hydrochloride USP24 amodiaquin dihydrochloride dihydrate Amodiaquin dihydrochloride dihydrate AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol 5-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol dihydrochloride 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol dihydrochloride 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol dihydrochloride dihydrate |
CAS | 6398-98-7 |
EINECS | 642-210-0 |
InChI | InChI=1/C20H22ClN3O.2ClH/c1-3-24(4-2)13-14-5-7-16(12-20(14)25)23-18-9-10-22-19-11-15(21)6-8-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H |
Molecular Formula | C20H24Cl3N3O |
Molar Mass | 428.78 |
Boling Point | 535.4°C at 760 mmHg |
Flash Point | 277.6°C |
Solubility | Soluble in DMSO or methanol |
Vapor Presure | 4.47E-12mmHg at 25°C |
Appearance | neat |
Color | White to Yellow to Orange |
Maximum wavelength(λmax) | ['342nm(MeOH)(lit.)'] |
Merck | 14,572 |
Storage Condition | Inert atmosphere,Room Temperature |
Use | Used as an antimalarial drug |
In vivo study | In vivo experiments in dogs, small doses of amodiaquine significantly enhanced the effect of histamine on gastric secretion. In mice with P. acnes-primed and LPS-induced hepatitis, treatment with amodiaquine effectively prevented severe liver injury and high lethality, enhancing the elevation of histamine without increasing tele-methylhistamine (t-MeHA). |
WGK Germany | 3 |
RTECS | GO7300100 |
HS Code | 2933492250 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.151 ml | 10.757 ml | 21.514 ml |
5 mM | 0.43 ml | 2.151 ml | 4.303 ml |
10 mM | 0.215 ml | 1.076 ml | 2.151 ml |
5 mM | 0.043 ml | 0.215 ml | 0.43 ml |